eagle-i University of Texas at San AntonioUniversity of Texas at San Antonio
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Seshu Laboratory

eagle-i ID

http://utsa.eagle-i.net/i/00000137-ec73-07dc-4d36-56dd80000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "The major research focus has been on characterizing the molecular basis of the host-pathogen interactions of infectious agents that are transmitted to humans and domestic animals by arthropod vectors. Our efforts are directed at 1) determining alterations in regulation of gene expression by pathogenic bacteria in response to disparate environmental signals encountered in the arthropod or vertebrate hosts; 2) delineating alterations in metabolic pathways commensurate with the host-dependent nutrient availability; 3) identification of biomarkers of vector-borne infections and inflammation; 4) validation of molecular therapeutics to ameliorate the symptoms of vector-borne infections, and 5) identification of targets as sensors of virulence and infection. Questions in the above areas are addressed by employing state of the art technologies in areas of Bioinformatics, Biochemistry, Molecular Biology, Proteomics, whole genome microarrays as well as protein-protein interactions. Established animal models and established collaborative efforts will be used to validate manipulation of the genomes of intractable, vector-borne pathogens."
  2. Additional Name
    CEIG Research Core 2 - Biochemistry & Molecular Biology of Vector Borne Pathogens
  3. PI
    Seshu, Janakiram, Ph.D.
  4. Affiliation
    Center of Excellence in Infection Genomics
  5. Affiliation
    South Texas Center for Emerging Infectious Diseases
  6. PI (co-Investigator)
    Chambers, James, Ph.D.
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    kcespedes
  3. contributor
    efleming
  4. created
    2012-06-14T14:29:13.305-05:00
  5. creator
    efleming
  6. modified
    2013-02-06T13:35:11.615-06:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016