See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.
Seshu Laboratory
eagle-i ID
http://utsa.eagle-i.net/i/00000137-ec73-07dc-4d36-56dd80000000
Resource Type
Properties
-
-
Resource Description
-
"The major research focus has been on characterizing the molecular basis of the host-pathogen interactions of infectious agents that are transmitted to humans and domestic animals by arthropod vectors. Our efforts are directed at 1) determining alterations in regulation of gene expression by pathogenic bacteria in response to disparate environmental signals encountered in the arthropod or vertebrate hosts; 2) delineating alterations in metabolic pathways commensurate with the host-dependent nutrient availability; 3) identification of biomarkers of vector-borne infections and inflammation; 4) validation of molecular therapeutics to ameliorate the symptoms of vector-borne infections, and 5) identification of targets as sensors of virulence and infection.
Questions in the above areas are addressed by employing state of the art technologies in areas of Bioinformatics, Biochemistry, Molecular Biology, Proteomics, whole genome microarrays as well as protein-protein interactions. Established animal models and established collaborative efforts will be used to validate manipulation of the genomes of intractable, vector-borne pathogens."
-
-
Additional Name
-
CEIG Research Core 2 - Biochemistry & Molecular Biology of Vector Borne Pathogens
-
-
PI
-
Seshu, Janakiram, Ph.D.
-
-
Affiliation
-
Center of Excellence in Infection Genomics
-
-
Affiliation
-
South Texas Center for Emerging Infectious Diseases
-
-
PI (co-Investigator)
-
Chambers, James, Ph.D.
