eagle-i University of Texas at San AntonioUniversity of Texas at San Antonio
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Lopez-Ribot Laboratory

eagle-i ID

http://utsa.eagle-i.net/i/00000137-ec83-5963-4d36-56dd80000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "My laboratory studies the opportunistic pathogenic fungus Candida albicans. C. albicans is part of the normal human microbiota. However, as an opportunistic pathogen it is capable of causing overt disease (candidiasis), but usually only in hosts with defective immunity. The frequency of candidiasis has increased dramatically in the last decades as a result of an expanding population of immunocompromised patients. As a result, candidiasis is now the fourth most common nosocomial infections. The seriousness of this problem is heightened by the fact that, even with treatment using available antifungal agents, mortality rates lie in the 30- 40% range for these infected patients. As an opportunistic pathogen, it is clear that mechanisms of host immunity and pathogen virulence intertwine, giving rise to the highly complex nature of host-fungus interactions. However, the interplay between host immunity and fungal virulence has traditionally been ignored and most investigations into these topics are overwhelmingly “one-sided” which has resulted in a dangerous dichotomy between “microorganism-centered” and “host-centered” views of candidal pathogenesis. Thus, studies in my laboratory try to integrate these two facets to better understand and offer a more global perspective of C. albicans pathogenesis. Results have already provided new paradigms in the host-fungus relationship during candidiasis.Some of the highlights of this research program are: 1) Role of filamentation in virulence. 2) Biofilms 3) Development of novel immune-based strategies to combat candidiasis"
  2. Additional Name
    CEIG Core 3a - Immunopathogenesis of Fungal Infections and Anti-Fungal Drug Development
  3. PI
    Lopez-Ribot, Jose, Ph.D.
  4. Affiliation
    Center of Excellence in Infection Genomics
  5. Secondary affiliation
    South Texas Center for Emerging Infectious Diseases
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    kcespedes
  3. created
    2012-06-14T14:45:56.946-05:00
  4. creator
    efleming
  5. modified
    2013-02-05T11:24:44.336-06:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016