Blood, the vascular tissue, is vital for nutrient transport, immune-surveillance, hemostasis, and wound healing, which maintain normal physiology. A number of cardiovascular diseases can be traced to an imbalance in the otherwise tightly regulated interactions between different cellular and acellular components (such as proteins and lipids) of blood. Since blood is a flowing fluid, the cells and molecules constantly experience different types and magnitudes of force, which can influence their interactions, and hence the fine line between health and disease.
Our approach is multidimensional, which takes into account the physical, chemical and biological effects in blood for reliable understanding of cardiovascular diseases, and treating them effectively. We use a number of techniques drawn from fields as disparate as Chemical Engineering, Materials Science, Biology and Medicine to understand the causes of cardiovascular diseases, and develop treatment methodologies. Our research has both fundamental and applied components: on one hand, we improve our mechanistic understanding of these disorders such as abnormal cell adhesion or changes in cellular physiology, and on the other, develop new devices for treating these disorders, such as drug screening and delivery systems.
Ramasubramanian, Anand K., Ph.D.
Role: Director, Vascular Bioengineering Lab