We study the circuitry and neurons of the basal ganglia, with the goal of understanding the computational function of these structures at the cellular level, and their dysfunction in diseases, especially Parkinson’s Disease. Our experiments are focused on the ionic mechanisms that endow each cell type with its characteristic responses to synaptic input, the patterns of connectivity that deliver specific inputs to each cell, and the dynamics that arise from the combination of these.
" This is the beginning of a new Mac program for data analysis of calcium imaging data taken with Jay Callaway’s CCD program. It doesn’t do everything yet, but it is useful for getting information from the files. It can display full frame views, make reports, and display sequences as movies. It can also save sequences as quicktime movies. It’s functions can all be performed using applescript as well as interactively. At this point, it can’t yet draw graphs."
" Oscilloscope is a Macintosh program for visualization and analysis of waveforms generated by neurons or by computer simulations of neurons. The current version (version 4.5) is a carbon universal application that works in OS X. Oscilloscope can analyze waveforms generated in a variety of ways and by a host of other programs, because it can read and write data stored in two simple and widely-used file formats. One of these is the tab-delimited text file format used by spreadsheets and many graphics programs. The other is a binary format, the HDF scientific data format described and supported by the National Center for Supercomputing Applications (NCSA) and used by a large number of commercial and freeware programs. Oscilloscope can also read Axon Binary Files (version 1.6) created by the popular PClamp data acquisition software. The waveforms are seen as if on the screen of a digital oscilloscope. As many as 10 files may be open at any time, and the traces from each are shown in a window representing the file. Each file can contain up to 100 different waveforms (called traces) that can be seen simultaneously. Traces can be selectively hidden or shown by choosing them from a menu that lists them by name. The vertical gain of each trace can be adjusted individually, as can its vertical position on the screen. Likewise, the sweep speed and horizontal position of each trace can be adjusted. There is (practically) no limit to the number of points in a trace, but all traces in a file must have the same number of points and the same time increment between points. The typical appearance of traces on the screen is illustrated below. "