eagle-i University of Texas at San AntonioUniversity of Texas at San Antonio
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Seshu Laboratory

Summary:

The major research focus has been on characterizing the molecular basis of the host-pathogen interactions of infectious agents that are transmitted to humans and domestic animals by arthropod vectors. Our efforts are directed at 1) determining alterations in regulation of gene expression by pathogenic bacteria in response to disparate environmental signals encountered in the arthropod or vertebrate hosts; 2) delineating alterations in metabolic pathways commensurate with the host-dependent nutrient availability; 3) identification of biomarkers of vector-borne infections and inflammation; 4) validation of molecular therapeutics to ameliorate the symptoms of vector-borne infections, and 5) identification of targets as sensors of virulence and infection.

Questions in the above areas are addressed by employing state of the art technologies in areas of Bioinformatics, Biochemistry, Molecular Biology, Proteomics, whole genome microarrays as well as protein-protein interactions. Established animal models and established collaborative efforts will be used to validate manipulation of the genomes of intractable, vector-borne pathogens.

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Last updated: 2013-02-06T13:35:11.615-06:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016