The research in our laboratory utilizes the human fungal pathogen Cryptococcus neoformans as a model organism to study host-fungal interactions for the purpose of developing novel immune therapies and/or vaccines to treat or prevent invasive fungal infections. C. neoformans, the causative agent of cryptococcosis, is an opportunistic fungal pathogen that has the propensity to cause respiratory tract infections in severely immune compromised individuals and possesses a unique predilection to invade the central nervous system causing life-threatening meningoencephalitis.
We focus our research in three main areas:
1) To define protective host immune responses against C. neoformans infections.
2) To identify targets for anti-fungal drug development.
3) To characterize C. neoformans biofilm-forming conditions.
Wozniak, Karen, Ph.D.
Role: Assistant Professor of Researcher